TPO Antibody (DA114)
TPO Antibody (DA114)
Recombinant monoclonal rabbit antibody
Description
Thyroid Peroxidase (TPO) is an enzyme expressed mainly in the thyroid where it is secreted into colloid. Thyroid peroxidase oxidizes iodide ions to form iodine atoms for addition onto tyrosine residues on thyroglobulin for the production of thyroxine (T4) or triiodothyronine (T3), the thyroid hormones. In humans, thyroperoxidase is encoded by the TPO gene. The TPO gene consists of 17 exons, and is located on the short arm of chromosome 2. Thyroid Peroxidase gene expression is under the regulation of thyroid stimulating hormone. In normal thyroid, expression of TPO described immunohistochemically is reported to produce a diffuse, fine, granular cytoplasmic stain in all follicular cells. TPO labels normal thyroid epithelial cells and thyroid tumor cells.The expression level in thyroid carcinomas is lower than that of normal and benign thyroid tumors. Decreased TPO immunoreactivity is an early event in follicular tumourigenesis, taking place before development of invasiveness in parallel with an acceleration of cell growth and appearance of cell atypia.1-8
References
2. Kuliawat R, et al.: J Biol Chem 2005, 280:27713-27718
3. Strum JM, et al.: J Cell Biol 1970, 44:655-666
4. Roddiger SJ, et al.: J Mol Endocrinol 2002, 29:287-295
5. Lima MA, et al.: Endocr Pathol 1998, 9:333-338
6. De Micco C, et al.: Thyroid 2000, 10:109-115
7. Franke WG, et al.: Anticancer Res 1999, 19:2711-2716
8. U.S. Department of Health and Human Services: Centers for Disease Control and Prevention. Guidelines for Safe Work Practices in Human and Animal Medical Diagnostic Laboratories. Supplement / Vol. 61, January 6, 2012.
Specifications
Order information
| RMB1A115 | Concentrate | IVD(R) |
| RMB1A115 | 10 ml Ready to use | IVD(R) |
| RMB1A115 | 6 ml Ready to use | IVD(R) |
| RMB1A115 | 3 ml Ready to use | IVD(R) |
