Arginase-1 Antibody (DA139)
Arginase-1 Antibody (DA139)
Recombinant monoclonal rabbit antibody
Description
Arginase is a key metalloenzyme of the urea cycle responsible for the hydrolysis of L-arginine to L-ornithine and urea.1 Two main isoforms exist, arginase-1 and arginase-2, encoded by different genes and with different tissue distributions. The arginase-1 isoform is a cytosolic protein that is produced by normal liver tissue and is typically expressed in hepatocellular carcinoma.1-3 Arginase-1 is used as an immunohistochemical marker to aid in the identification of hepatocellular carcinoma.3,4
References
1. McKnight, Ryan et al. "Arginase-1: a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology." Cancer cytopathology vol. 120,4 (2012): 223-9.
2. Sang, Wei et al. "Arginase-1 is a more sensitive marker than HepPar-1 and AFP in differential diagnosis of hepatocellular carcinoma from nonhepatocellular carcinoma." Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine vol. 36,5 (2015): 3881-6.
3. Yan, Benjamin C et al. "Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms." The American journal of surgical pathology vol. 34,8 (2010): 1147-54.
4. Clark, Ian et al. "A subset of well-differentiated hepatocellular carcinomas are Arginase-1 negative." Human pathology vol. 69 (2017): 90-95.
2. Sang, Wei et al. "Arginase-1 is a more sensitive marker than HepPar-1 and AFP in differential diagnosis of hepatocellular carcinoma from nonhepatocellular carcinoma." Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine vol. 36,5 (2015): 3881-6.
3. Yan, Benjamin C et al. "Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms." The American journal of surgical pathology vol. 34,8 (2010): 1147-54.
4. Clark, Ian et al. "A subset of well-differentiated hepatocellular carcinomas are Arginase-1 negative." Human pathology vol. 69 (2017): 90-95.
Specifications
Application:
IHC (FFPE)
Host:
Rabbit
Subclass:
IgG
Immunogen:
Synthetic peptide from human Arginase-1
Cellular location:
Cytoplasm/Nucleus
Control:
Liver
Order information
| DMRD0173 | Concentrate | IVD(R) |
| DMRD0173 | 10 ml Ready to use | IVD(R) |
| DMRD0173 | 6 ml Ready to use | IVD(R) |
| DMRD0173 | 3 ml Ready to use | IVD(R) |
