CD20 Antibody (DA144)
CD20 Antibody (DA144)
Recombinant monoclonal rabbit antibody
Description
CD20 is a transmembrane protein in late B-cell precursors and mature B-cells that plays a role in regulating proliferation and differentiation. CD20 expression is lost at the plasma cell stage of differentiation.1 Anti-CD20 (pan B-cell)2 has rarely been detected in T-cell malignancies, and is a dependable marker of B-cell lymphomas3 such as DLBCL.4 CD20 expression is present in some thymomas.
References
1. Tedder T, et al. CD20: a regulator of cell-cycle progression of B lymphocytes. Immunol Today. 1994; 15:450-4.
2. Mason DY, et al. Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen. Am J Pathol. 1990; 136:1215-22.
3. Norton AJ, et al. Monoclonal antibody L26: an antibody that is reactive with normal and neoplastic B lymphocytes in routinely fixed and paraffin wax embedded tissues. J Clin Pathol. 1987; 40:1405-12.
4. Suzuki Y, et al. Association of CD20 levels with clinicopathological parameters and its prognostic significance for patients with DLBCL. Ann Hematol. 2012; 91:997-1005.
2. Mason DY, et al. Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen. Am J Pathol. 1990; 136:1215-22.
3. Norton AJ, et al. Monoclonal antibody L26: an antibody that is reactive with normal and neoplastic B lymphocytes in routinely fixed and paraffin wax embedded tissues. J Clin Pathol. 1987; 40:1405-12.
4. Suzuki Y, et al. Association of CD20 levels with clinicopathological parameters and its prognostic significance for patients with DLBCL. Ann Hematol. 2012; 91:997-1005.
Specifications
Application:
IHC (FFPE)
Host:
Rabbit
Subclass:
IgG
Immunogen:
Synthetic peptide of human CD20
Cellular location:
Cell membrane
Control:
Tonsil
Order information
| DMRD0179 | Concentrate | IVD(R) |
| DMRD0179 | 10 ml Ready to use | IVD(R) |
| DMRD0179 | 6 ml Ready to use | IVD(R) |
| DMRD0179 | 3 ml Ready to use | IVD(R) |
